PENGARUH PEMBERIAN SUPLEMEN IKAN GABUS PADA STATUS NEUROLOGIS PASIEN STROKE ISKEMIK DI RUMAH SAKIT UMUM DAERAH PATUH PATUT PATJU
DOI:
https://doi.org/10.33651/jpkik.v7i2.243Keywords:
Snakehead fish Supplement, ischemic stroke, NIHSS, Barthel index (BI), Albumin SerumAbstract
Stroke is the leading cause of death and disability in a world that requires treatment and care in the long term. Many factors that influence the outcome and the level of worsening after ischemic stroke include hypoalbumin which is one of the factors affecting the outcome of stroke. This study to determine the effect of supplementation of Snakehead fish on neurological improvement ischemic stroke patients at Patuh Patut Patju hospital.
This study included quasi experimental research with Sparate Samples Pretest-Posttest design, Pre treatment ischemic stroke patients who have not given supplements of Snakehead fish (H1) and post treatment of ischemic stroke patients who have been given supplement Snakehead fish dose 3 times a day for 14 day (H14). Clinical outcome in grades of serum albumin levels, NIHSS and Barthel index. Analysis outcome with SPSS Shapiro wilk test, Wilcoxon signed test , and Mann whitney testOutcome post treatment decrease NIHSS score (p = 0,000, <0,05), increased Barthel index score (p = 0,000, <0,05), increased serum albumin level (p = 0.000, <0,05). Snakehead fish supplement can decrease NIHSS score, increase barthel index score and serum albumin level post given for 14 day.
References
Adam, R., Victor M, Ropper AH. (2001). Principles of Neurology, McGraw-Hill, New York.
Andhyka I., 2017. Analisis efektifitas biaya pemberian suplemen ikan gabus pada pasien stroke iskemik di RSUD Patuh Patut Patju Lombok Barat. Surabaya: UBAYA.
Baselli M, AR at al. 2012 Supplementation of Esensial Amino Acids Mey Reduce the Occorence in Infections In Rehabilitation patients whit Brain Injury.
Belayev, L., Liu, Y., Zhao, W., Busto, R., and Ginsberg, M.D., 2001. Human albumin therapy of acute ischemic stroke. Marked neuroprotective efficacy at moderate doses and with a broad therapeutic window. Stroke. 32: 553–560.
Catur.Wipadyana. 2016. Derajat Hipoalbumin Sedang Sebagai Prediktor Luaran Buruk Pada Penderita Stroke Iskemik Akut program Pascasarjana Universitas Udayana Denpasar.
Corrigan ML at al.2011 Nurtition in the stroke patients in clinical practice.26(3)242-52
Dziedzic, T, Slowik, A, and Szczudlik, A., 2004, Serum albumin level as a predictor of ischemic stroke outcome. Stroke. 35:e156.
Dziedzic, T., Pera, J., Slowik, A., Gryz-Kurek, EA., and Szczudlik, A., 2007, Hypoalbuminemia in Acute Ischemic Stroke Patients: Frequency and Correlates. European Journal of Clinical Nutrition. 61, 1318–1322.
Gariballa, S.E Parker.S.G aub.N.1998. Influence of nutritional status on clinical outcome after acute stroke. 68:275-81.
Ginsberg, M.D., Hill, M.D., Palesch, Y.Y., Ryckborst, K., and Tamariz, D., 2006. The ALIAS Pilot Trial. A dose-Escalation and Safety of Albumin Therapy for Acute Ischemic Stroke – I: Physiological Responses and Safety Resul ts. Stroke. 37: 2100 – 2106.
Marlina, Y. 2011. Gambaran Faktor Risiko pada Penderita Stroke Iskemik di RSUP H. Adam Malik Medan Tahun 2010. Skripsi Sarjana (Diterbitkan). Medan: Universitas Sumatera Utara.
Mukherjee D, Patil CG. Epidemiology and the global burden of stroke. World Neurosurg. 2011;76(6):S85-90.doi:10.1016/j.wneu. 2011.07.023.
Mulyati,2007. Efek Pemberian kapsul albumin ikan gabus terhadap perubahan status gizi dan status neurologis penderita stroke di RSUD dr.Wahidin, Makasar program pasca sarjana UNHAS.
Murray, R.G., 2006. Plasma protein & immunoglobulins in: Murray, R.K. Granner, D.K., Rodwell, V.W.(eds). Harper’s Iiiustrated biochemistry. 27 th ed. Pp.588-606. McGraw-Hill.New York.
Nayak AR,Kashyap RS at al.2011 Prognostic Significance of Iskeic Modifide Albumi in acute stroke patient.18 (1)
Notoatmodjo, S., 2012. Metodologi Penelitian Kesehatan. Jakarta: Rineka Cipta.
Palesch, Y, Hill M.D Ryckborst, K.J Tamariz D, Gisbreg M.D.2006. The Alias Pilot Trial.A dose-Escalation and safety of albumin terapy of acute iskemik stroke.37:2107-2114.
Palomares SN, Cipola MJ, at al, Protection Following Cerebral Iskemic dan Reperfusion, Neural Neurophysiol 2011: 1-24
Ratnaningsih, 2014, Pengaruh Suplementasi EIG terhadap Status Protein, Antioksidan dan Stres Oksidatif. Disertasi Universitas Diponogoro Semarang.
William, L.S, yilmaz, E.Y., Yunez, A.M.L. 2000. Retrospective assessment of initiall stroke severity with the NIH Stroke Scales. Stroke. 31:858-862.
Yulianto, A., 2011. Mengapa stroke menyerang usia muda?: penyebab, gejala, dan pencegahan stroke yang menyerang usia muda. Yogyakarta: Javalitera.
Dirnagl, U., Iadecola, C., and Moskowitz, M.A., 2005. Pathobiology of Ischaemic Stroke: an Integrated View. Trends Neurosci. 22, 391–397.
World Health Organization. Non communicable diseases [Internet]. 2013 http://www.who.int/mediacentre/factsheets/fs355/en/.
